{"id":7981,"date":"2025-06-27T07:39:08","date_gmt":"2025-06-27T04:39:08","guid":{"rendered":"https:\/\/oudensxolion.gr\/?p=7981"},"modified":"2025-06-27T07:39:08","modified_gmt":"2025-06-27T04:39:08","slug":"%cf%80%cf%89%cf%82-%cf%84%ce%b1-%ce%b5%ce%bc%ce%b2%cf%8c%ce%bb%ce%b9%ce%b1-mrna-%ce%bc%cf%80%ce%bf%cf%81%ce%bf%cf%8d%ce%bd-%ce%bd%ce%b1-%cf%80%cf%81%ce%bf%ce%ba%ce%b1%ce%bb%ce%ad%cf%83%ce%bf%cf%85","status":"publish","type":"post","link":"https:\/\/oudensxolion.gr\/?p=7981","title":{"rendered":"\u03a0\u03c9\u03c2 \u03c4\u03b1 \u03b5\u03bc\u03b2\u03cc\u03bb\u03b9\u03b1 mRNA \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd \u03ae \u03bd\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 &#8211; \u03a3\u03bf\u03ba \u03b1\u03c0\u03cc \u03bd\u03ad\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b4\u03af\u03bd\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf Mc Cullough Foundation &#8211; \u03a3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03b1\u03bd\u03b7\u03c3\u03c5\u03c7\u03af\u03b5\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03b9\u03b1 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7, \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc 100 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2, \u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03b1\u03bd\u03b7\u03c3\u03c5\u03c7\u03af\u03b5\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03b5\u03bd\u03ad\u03c3\u03b5\u03c9\u03bd mRNA \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7, \u03c0\u03bf\u03c5 \u03b4\u03af\u03bd\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf Mc Cullough Foundation, \u03bf\u03b9 \u03b5\u03bd\u03ad\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd, \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03b1\u03c7\u03cd\u03bd\u03bf\u03c5\u03bd \u03ae \u03bd\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03bc\u03ad\u03c3\u03c9 17 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03ce\u03bd \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bf\u03b4\u03ce\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bf\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9, \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03bc\u03b9\u03b1 \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b7 \u03b5\u03be\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03ba\u03ac\u03b8\u03b5 \u03ad\u03bd\u03b1\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1. \u0391\u03c3\u03c4\u03ac\u03b8\u03b5\u03b9\u03b1 \u0393\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2<br>\u03a4\u03bf mRNA \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03b5\u03bd\u03ad\u03c3\u03b5\u03b9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af, \u03c5\u03c0\u03cc \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c3\u03c5\u03bd\u03b8\u03ae\u03ba\u03b5\u03c2, \u03bd\u03b1 \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03c9\u03b8\u03b5\u03af \u03c3\u03c4\u03bf \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03bf DNA, \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ce\u03bd\u03c4\u03b1\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03bd\u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03bf\u03b3\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2. \u0391\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u0394\u03b9\u03b1\u03c6\u03c5\u03b3\u03ae<br>\u0397 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 Spike, \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03b5\u03bd\u03ad\u03c3\u03b5\u03b9\u03c2, \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03cc\u03b3\u03ba\u03c9\u03bd, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf p53, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3. \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03b3\u03bc\u03ad\u03bd\u03b7 \u0395\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 DNA<br>\u0397 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 Spike \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03c4\u03b1 \u03ad\u03bd\u03b6\u03c5\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b4\u03b9\u03bf\u03c1\u03b8\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf DNA, \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b2\u03bb\u03b1\u03b2\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">4. \u03a7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03a6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae<br>\u03a4\u03b1 \u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ac \u03bd\u03b1\u03bd\u03bf\u03c3\u03c9\u03bc\u03b1\u03c4\u03af\u03b4\u03b9\u03b1 (LNPs) \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b5\u03bd\u03ad\u03c3\u03b5\u03b9\u03c2, \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 Spike, \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03bf\u03c4\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">5. \u039a\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u0391\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03a3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2<br>\u039f\u03b9 \u03b5\u03bd\u03ad\u03c3\u03b5\u03b9\u03c2 mRNA \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03c9\u03bd \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2, \u03b1\u03c0\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03bd\u03b1 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">6. \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae RNA<br>\u0397 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03bd\u03af\u03c9\u03bd \u03c3\u03c4\u03bf mRNA \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03bc\u03b9\u03ba\u03c1\u03bfRNA, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03b1\u03af\u03b6\u03bf\u03c5\u03bd \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">7. \u039f\u03b3\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03a3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7<br>\u0397 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 Spike \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03bf\u03b4\u03bf\u03cd\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 PI3K\/mTOR \u03ba\u03b1\u03b9 MAPK, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03cc\u03c4\u03b9 \u03c0\u03c1\u03bf\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">8. \u039c\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd \u038c\u03b3\u03ba\u03bf\u03c5<br>\u03a4\u03b1 LNPs \u03c4\u03b5\u03af\u03bd\u03bf\u03c5\u03bd \u03bd\u03b1 \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2, \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03bc\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd \u03c0\u03bf\u03c5 \u03b5\u03c5\u03bd\u03bf\u03b5\u03af \u03c4\u03b7\u03bd \u03b5\u03be\u03ac\u03c0\u03bb\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">9. \u0395\u03c0\u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac \u0391\u03b4\u03c1\u03b1\u03bd\u03ce\u03bd \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bd<br>\u039f\u03b9 \u03b5\u03bd\u03ad\u03c3\u03b5\u03b9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03ac\u03be\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03bb\u03b1\u03bd\u03b8\u03b1\u03bd\u03cc\u03bd\u03c4\u03c9\u03bd \u03cc\u03b3\u03ba\u03c9\u03bd, \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03bd \u03c3\u03b5 \u03cd\u03c6\u03b5\u03c3\u03b7.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">10. \u0391\u03c0\u03bf\u03c4\u03c5\u03c7\u03af\u03b1 \u0391\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u0395\u03c0\u03b9\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2<br>\u03a4\u03bf \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf RNA (m1\u03a8) \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03c4\u03cd\u03c0\u03bf\u03c5 toll, \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bd\u03b1 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b5\u03b9 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">11. \u03a3\u03c6\u03ac\u03bb\u03bc\u03b1\u03c4\u03b1 \u039c\u03b5\u03c4\u03b1\u03c4\u03cc\u03c0\u03b9\u03c3\u03b7\u03c2 \u03a0\u03bb\u03b1\u03b9\u03c3\u03af\u03bf\u03c5<br>\u0397 \u03bc\u03b5\u03c4\u03ac\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 mRNA \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03bc\u03b7 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b5\u03bd\u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd \u03b2\u03bb\u03b1\u03b2\u03b5\u03c1\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03b3\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">12. \u0395\u03be\u03ac\u03bd\u03c4\u03bb\u03b7\u03c3\u03b7 \u0391\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03a3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2<br>\u039f\u03b9 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 (\u03b5\u03bd\u03b9\u03c3\u03c7\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2) \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae IgG4, \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c7\u03ae \u03c0\u03bf\u03c5 \u03b5\u03c5\u03bd\u03bf\u03b5\u03af \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">13. \u039c\u03cc\u03bb\u03c5\u03bd\u03c3\u03b7 DNA<br>\u03a0\u03bb\u03b1\u03c3\u03bc\u03b9\u03b4\u03b9\u03b1\u03ba\u03cc DNA \u03c0\u03bf\u03c5 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b1\u03c1\u03c4\u03af\u03b4\u03b5\u03c2 \u03b5\u03bc\u03b2\u03bf\u03bb\u03af\u03c9\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03c9\u03b8\u03b5\u03af \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03be\u03b5\u03bd\u03b9\u03c3\u03c4\u03ae, \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae\u03c2 \u03b1\u03c3\u03c4\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">14. \u0391\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b5\u03c2 SV40<br>\u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03b9\u03ce\u03bd SV40, \u03b5\u03bd\u03cc\u03c2 \u03b3\u03bd\u03c9\u03c3\u03c4\u03bf \u03bf\u03b3\u03ba\u03bf\u03b3\u03cc\u03bd\u03bf \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1, \u03c3\u03b5 \u03c6\u03b9\u03b1\u03bb\u03af\u03b4\u03b9\u03b1 \u03c4\u03b7\u03c2 Pfizer \u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03b9 \u03b1\u03bd\u03b7\u03c3\u03c5\u03c7\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03bb\u03ae \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">15. \u0391\u03c0\u03bf\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 RAS<br>\u0397 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 Spike \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03b5\u03c1\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 AT1R, \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03b5\u03be\u03ad\u03bb\u03b5\u03b3\u03ba\u03c4\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">16. \u0392\u03bb\u03ac\u03b2\u03b7 \u03c3\u03c4\u03bf \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03af\u03c9\u03bc\u03b1<br>\u0397 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c5\u03b5\u03c1\u03b3\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03c9\u03bd, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 \u03bc\u03c0\u03b9\u03c6\u03b9\u03b4\u03bf\u03b2\u03b1\u03ba\u03c4\u03ae\u03c1\u03b9\u03b1, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ae \u03ac\u03bc\u03c5\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">17. \u0391\u03bd\u03c4\u03bf\u03c7\u03ae \u03c3\u03c4\u03b7 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<br>\u0397 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 Spike \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03b4\u03c5\u03c3\u03c7\u03b5\u03c1\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03b5\u03bd\u03ad\u03c3\u03b5\u03c9\u03bd mRNA \u03c3\u03c4\u03b7\u03bd \u03c5\u03b3\u03b5\u03af\u03b1, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf. \u039f\u03b9 \u03c3\u03c5\u03b3\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03b3\u03bd\u03cc\u03b7\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03bd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03c9\u03bd \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b7\u03bc\u03cc\u03c3\u03b9\u03b1 \u03c5\u03b3\u03b5\u03af\u03b1. \u0395\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03b7 \u03b4\u03b9\u03b5\u03be\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03c9\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03c0\u03b1\u03bd\u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c5\u03c0\u03b1\u03c1\u03c7\u03bf\u03c5\u03c3\u03ce\u03bd \u03c0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ce\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03b5\u03bc\u03b2\u03bf\u03bb\u03af\u03c9\u03bd, \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b5\u03af \u03b7 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03ce\u03bd \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03b7\u03b3\u03ae:<a href=\"https:\/\/mcculloughfnd.org\/\">&nbsp;https:\/\/mcculloughfnd.org\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"> <a href=\"https:\/\/www.focusfm.gr\/\">https:\/\/www.focusfm.gr\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 &#8211; \u03a3\u03bf\u03ba \u03b1\u03c0\u03cc \u03bd\u03ad\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b4\u03af\u03bd\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf Mc Cullough Foundation &#8211; \u03a3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03b1\u03bd\u03b7\u03c3\u03c5\u03c7\u03af\u03b5\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u039c\u03b9\u03b1 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ae 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[&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":7982,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7981","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1"],"_links":{"self":[{"href":"https:\/\/oudensxolion.gr\/index.php?rest_route=\/wp\/v2\/posts\/7981","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oudensxolion.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/oudensxolion.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/oudensxolion.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/oudensxolion.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7981"}],"version-history":[{"count":1,"href":"https:\/\/oudensxolion.gr\/index.php?rest_route=\/wp\/v2\/posts\/7981\/revisions"}],"predecessor-version":[{"id":7983,"href":"https:\/\/oudensxolion.gr\/index.php?rest_route=\/wp\/v2\/posts\/7981\/revisions\/7983"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/oudensxolion.gr\/index.php?rest_route=\/wp\/v2\/media\/7982"}],"wp:attachment":[{"href":"https:\/\/oudensxolion.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7981"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/oudensxolion.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7981"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/oudensxolion.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}